Ammonia → HCID 57417082, compound

HRID 1807668Notes

Reaction equation

HRID 1807668 reaction equation
C([O:5][C:6]([C@@H:8]1[CH2:12][C@H:11]([N:13]([CH3:15])[CH3:14])[CH2:10][NH:9]1)=O)CCC.[NH3:16]>CO>[CH3:14][N:13]([CH3:15])[C@@H:11]1[CH2:10][NH:9][C@H:8]([C:6]([NH2:16])=[O:5])[CH2:12]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58092718HCID 58092718, compound

Product 1

HCID 57417082HCID 57417082, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (2S,4S)-4-dimethylamino-pyrrolidine-2-carboxylic acid butyl ester (Stage Q.1, 326 mg) and 7 M ammonia in MeOH (8 ml) was stood for 18 h at it in a sealed vessel. Filtration, evaporation and trituration with Et2O/MeOH gave the title compound as a beige solid.

Workup

  1. filtrationFiltration, evaporation and trituration with Et2O/MeOH

Sources & evidence

ORD record
ord-f46b9aa8b934416aba7cc6d2392125d6
Source dataset
uspto-grants-2013_01
Patent number
US08357707B2

Reaction notes

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