反应详情

4-Nitrophenyl carbonochloridate (0.217 mmol, 43.7 mg) was added to a stirred solution of (4-aminophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-piperazin-1-yl)methanone (0.217 mmol, 100 mg) in dichloromethane (1 mL). After 1 hour, 1-amino-2-methylpropan-2-ol (0.650 mmol, 58.0 mg) was added and stirring continued for 1 hour. The reaction mixture was purified by silica column chromatography (eluant dichloromethane/methanol 0% to 10%) to yield the title compound (30 mg).

1. waitcontinued for 1 hour
2. customThe reaction mixture was purified by silica column chromatography (eluant dichloromethane/methanol 0% to 10%)