反应详情

2-(4-((4-(3-Aminophenylsulfonyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.302 mmol, 150 mg) and 4-nitrophenyl carbonochloridate (0.302 mmol, 60.8 mg) were combined in a mixture of dichloromethane/dimethylformamide and stirred at room temperature for 1 hour. Cyclopropylmethanamine (0.603 mmol, 42.9 mg) was added and the reaction mixture was left to stir at room temperature for 15 minutes. The reaction mixture was purified by SCX chromatography and concentrated under vacuum. The residue was purified by silica column chromatography, eluting with 0%-4% methanol/dichloromethane gradient, to afford the title compound (52.3 mg).

1. waitthe reaction mixture was left
2. stirringto stir at room temperature for 15 minutes
3. customThe reaction mixture was purified by SCX chromatography
4. concentrationconcentrated under vacuum
5. customThe residue was purified by silica column chromatography
6. washeluting with 0%-4% methanol/dichloromethane gradient