Sodium Iodide → 3-Hydroxy-4-iodobenzoic acid

HRID 1808297Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[I-:11].[Na+].Cl[O-].[Na+]>>[I:11][C:10]1[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=1[OH:1]

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 74203-Hydroxybenzoic Acid

HCID 23665760Sodium Hypochlorite

Product 1

HCID 7368543-Hydroxy-4-iodobenzoic acid

Procedure

3-Hydroxybenzoic acid (V) is iodinated in the presence of sodium iodide and of sodium hypochlorite in order to give 4-iodo-3-hydroxybenzoic acid (VI).

Sources & evidence

ORD record: ord-9e46445f3bb4443aaff1b59686b81d5c
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08357819B2

Reaction notes

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