Acetyl chloride → HCID 11429511, compound

Participants

Reaction Conditions

Reaction Steps

25 g (0.186 mol) of methyl dimethoxyacetate are added to 27 ml (0.215 mol) of acetyl chloride at ambient temperature. 0.1 g (0.2 mol %) of diiodine are added and then the reaction mixture is stirred at 55° C. for 16 hours. The excess acetyl chloride is evaporated under vacuum and then the residue is dissolved in 100 ml of dichloromethane. 49 g (0.204 mol) of triphenylphosphine are added and then the reaction mixture is stirred at 37° C. for 3 hours. The solvents are evaporated and then the residue is crystallized from diisopropyl ether. 70 g of (methoxy(methoxycarbonyl)methyl)triphenylphosphonium chloride are obtained.

Provenance & Evidence