Acetyl chloride → HCID 11429511, compound

HRID 1808302Notes

Reaction equation

HRID 1808302 reaction equation
[CH3:1][O:2][CH:3](OC)[C:4]([O:6][CH3:7])=[O:5].C([Cl:13])(=O)C.[C:14]1([P:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>II>[Cl-:13].[CH3:1][O:2][CH:3]([P+:20]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:4]([O:6][CH3:7])=[O:5]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 11776TriphenylphosphineHCID 66647Acetic acid, 2,2-dimethoxy-, methyl ester

Product 1

HCID 11429511HCID 11429511, compoundYield 93.9%

Reagents, catalysts & solvents 1

HCID 807IodineCatalyst

Conditions

Temperature
55 °C

Procedure

25 g (0.186 mol) of methyl dimethoxyacetate are added to 27 ml (0.215 mol) of acetyl chloride at ambient temperature. 0.1 g (0.2 mol %) of diiodine are added and then the reaction mixture is stirred at 55° C. for 16 hours. The excess acetyl chloride is evaporated under vacuum and then the residue is dissolved in 100 ml of dichloromethane. 49 g (0.204 mol) of triphenylphosphine are added and then the reaction mixture is stirred at 37° C. for 3 hours. The solvents are evaporated and then the residue is crystallized from diisopropyl ether. 70 g of (methoxy(methoxycarbonyl)methyl)triphenylphosphonium chloride are obtained.

Workup

  1. customThe excess acetyl chloride is evaporated under vacuum
  2. dissolutionthe residue is dissolved in 100 ml of dichloromethane
  3. stirringthe reaction mixture is stirred at 37° C. for 3 hours
  4. customThe solvents are evaporated
  5. customthe residue is crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-7b9c6ca5a73a4fe9a7d41678b8c86144
Source dataset
uspto-grants-2013_01
Patent number
US08357819B2

Reaction notes

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