反应详情

Borane dimethylsulfide solution (0.3 ml, 94% in THF) was added at room temperature to a solution of the product from stage 1 (2.7 mmol) in dry THF (14 ml), and the mixture was refluxed for 2 h. Hydrolysis with methanol (1 ml) was carried out, followed by refluxing for a further 15 min. The reaction mixture was then cooled to room temperature and concentrated in vacuo. The crude product was purified by column chromatography (silica gel, ethyl acetate/hexane). Yield: 62%

1. temperaturethe mixture was refluxed for 2 h
2. temperatureby refluxing for a further 15 min
3. concentrationconcentrated in vacuo
4. customThe crude product was purified by column chromatography (silica gel, ethyl acetate/hexane)