反应详情

温度

0 °C

tert-Butyl 9-(pyridin-4-yloxy)-3-azaspiro[5.5]undecane-3-carboxylate (1 g, 2.886 mmol) was dissolved in methanol (2 ml); hydrogen chloride in methanol (1.25 mol/l, 11.5 ml) was added, and the mixture was refluxed for 30 min. The solvent was removed in vacuo and the residue was dissolved in a small amount of ethanol. Acetone (about 25 ml) was then added, the mixture was stirred for 30 min. at 0° C. and finally the resulting solid was filtered out with suction. Yield: 0.96 g (>99%)

1. temperaturethe mixture was refluxed for 30 min
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in a small amount of ethanol
4. additionAcetone (about 25 ml) was then added
5. filtrationfinally the resulting solid was filtered out with suction