反应详情

Lithium borohydride (0.232 g, 0.0107 mol) was added at 0° C., under argon, to a solution of methyl 1-(4-methoxy-2,6-dimethylphenylsulfonyl)indoline-6-carboxylate (1 g, 0.0027 mol) in dry THF (30 ml), and the resulting reaction mixture was refluxed for 2 h. The solvent was removed in vacuo, water was added to the residue, and extraction with ethyl acetate was carried out. The organic phase was washed with water and saturated sodium chloride solution, then dried (Na2SO4) and concentrated in vacuo. The resulting crude product was used in the next stage without further purification. Yield: 0.9 g (97%).

1. customthe resulting reaction mixture
2. temperaturewas refluxed for 2 h
3. customThe solvent was removed in vacuo, water
4. additionwas added to the residue, and extraction with ethyl acetate
5. washThe organic phase was washed with water and saturated sodium chloride solution
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated in vacuo
8. customThe resulting crude product was used in the next stage without further purification