Trifluoroacetic acid → HCID 59483827, compound

HRID 1808388Notes

Reaction equation

C(O)(C(F)(F)F)=O.[N:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:42][CH2:41][C:17]3([CH2:22][CH2:21][N:20]([C:23]([C:25]4[N:26]=[C:27]5[CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29][N:28]5[CH:40]=4)=[O:24])[CH2:19][CH2:18]3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1>C(Cl)Cl>[N:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:42][CH2:41][C:17]3([CH2:18][CH2:19][N:20]([C:23]([C:25]4[N:26]=[C:27]5[CH2:32][NH:31][CH2:30][CH2:29][N:28]5[CH:40]=4)=[O:24])[CH2:21][CH2:22]3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1

Participants

Conditions

Temperature: 25 °C

Procedure

TFA (2.5 ml) was added to a cooled (0° C.) solution of tert-butyl 2-(9-(pyridin-4-yl)-3,9-diazaspiro[5.5]undecane-3-carbonyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (0.86 mmol, 1.0 equiv.) in DCM (10 ml), and the mixture was stirred for 2 h at 25° C. When the reaction was complete (TLC monitoring), the solvent was removed in vacuo in order thus to yield the desired product in the form of a yellow solid. This was used directly in the next stage without further purification.

Workup

customthe solvent was removed in vacuo in order thus

Sources & evidence

ORD record: ord-b8f78a2a3c834e5f826b1241562cf0cc
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08357717B2

Reaction notes

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