HCID 66826252, compound → HCID 25012568, compound

HRID 1808545Notes

Reaction equation

HRID 1808545 reaction equation
Cl.Cl.[NH:3]1[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13]3[C:22]4[C:17](=[CH:18][C:19]([O:34][CH3:35])=[C:20]([O:23][CH2:24][CH2:25][N:26]5[CH2:30][CH2:29][C@H:28]([N:31]([CH3:33])[CH3:32])[CH2:27]5)[CH:21]=4)[N:16]=[C:15]([C:36]4[CH:37]=[C:38]([NH:42][C:43](=[O:47])[CH2:44][CH2:45][CH3:46])[CH:39]=[CH:40][CH:41]=4)[N:14]=3)=[CH:9][CH:10]=2)[CH:5]=[N:4]1>Cl>[NH:3]1[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13]3[C:22]4[C:17](=[CH:18][C:19]([O:34][CH3:35])=[C:20]([O:23][CH2:24][CH2:25][N:26]5[CH2:30][CH2:29][C@H:28]([N:31]([CH3:33])[CH3:32])[CH2:27]5)[CH:21]=4)[N:16]=[C:15]([C:36]4[CH:37]=[C:38]([NH:42][C:43](=[O:47])[CH2:44][CH2:45][CH3:46])[CH:39]=[CH:40][CH:41]=4)[N:14]=3)=[CH:9][CH:10]=2)[CH:5]=[N:4]1

Participants

3

Reactant 1

HCID 66826252HCID 66826252, compound

Product 1

HCID 25012568HCID 25012568, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The purified solid was taken up in HCl (4M in 1,4 dioxane, 2 mL) and stirred at RT for 2 h. The volatiles were removed in vacuo to give N-(3-(4-(1H-indazol-5-ylamino)-6-(2-((S)-3-(dimethylamino)pyrrolidin-1-yl)ethoxy)-7-methoxyquinazolin-2-yl)phenyl)butyramide di-hydrochloride salt (0.090 g, 0.132 mmol, 44% over two steps). MS 609 (M+1). HPLC retention time 4.30 mins.

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-8e461c700bc743bfa132f8ee0ccb6503
Source dataset
uspto-grants-2013_01
Patent number
US08357693B2

Reaction notes

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