Methanesulfonic Acid → Eprosartan Mesylate

Participants

Reaction Conditions

Reaction Steps

Crude eprosartan free base (50 gm, obtained in reference example 1) is stirred with isopropyl alcohol (750 ml), the reaction mass is cooled to 8° C. and then methane sulfonic acid (34 gm) is added drop wise to the mass at 0-5° C. The reaction mass is stirred for 5 hours 30 minutes at 0-5° C., the mass filtered, the material washed with isopropyl alcohol (138 ml) and then dried under vacuum at 45° C. to give 45.6 gm of crude eprosartan mesylate (HPLC purity: 98.7%).

Provenance & Evidence