反应详情

温度

8 °C

Crude eprosartan free base (50 gm, obtained in reference example 1) is stirred with isopropyl alcohol (750 ml), the reaction mass is cooled to 8° C. and then methane sulfonic acid (34 gm) is added drop wise to the mass at 0-5° C. The reaction mass is stirred for 5 hours 30 minutes at 0-5° C., the mass filtered, the material washed with isopropyl alcohol (138 ml) and then dried under vacuum at 45° C. to give 45.6 gm of crude eprosartan mesylate (HPLC purity: 98.7%).

1. filtrationthe mass filtered
2. washthe material washed with isopropyl alcohol (138 ml)
3. customdried under vacuum at 45° C.