Sodium Hydroxide → Eprosartan

HRID 1808668Notes

Reaction equation

HRID 1808668 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([OH:19])=[O:18])=[CH:15][CH:16]=2)[C:8](/[CH:20]=[C:21](/[C:28]([OH:30])=[O:29])\[CH2:22][C:23]2[S:27][CH:26]=[CH:25][CH:24]=2)=[CH:7][N:6]=1.C([O-])(=O)C.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([OH:19])=[O:18])=[CH:15][CH:16]=2)[C:8](/[CH:20]=[C:21](/[C:28]([OH:30])=[O:29])\[CH2:22][C:23]2[S:27][CH:26]=[CH:25][CH:24]=2)=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86643031Eprosartan acetate

Product 1

HCID 5281037EprosartanYield 91.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Eprosartan acetate (10 gm, obtained in example 1) is suspended in water (50 ml) at 25-30° C. and the pH of the suspension is adjusted to 7.0-7.25 with 5% sodium hydroxide solution (23 ml). The material is filtered, washed with water (20 ml) and then dried to give 8 gm of pure eprosartan free base (HPLC Purity: 99.85%).

Workup

  1. filtrationThe material is filtered
  2. washwashed with water (20 ml)
  3. customdried

Sources & evidence

ORD record
ord-ab447518fbf04ce48b41ab80a884c720
Source dataset
uspto-grants-2013_01
Patent number
US08361507B2

Reaction notes

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