Sodium Hydroxide → Eprosartan

Participants

Reaction Steps

Eprosartan acetate (10 gm, obtained in example 1) is suspended in water (50 ml) at 25-30° C. and the pH of the suspension is adjusted to 7.0-7.25 with 5% sodium hydroxide solution (23 ml). The material is filtered, washed with water (20 ml) and then dried to give 8 gm of pure eprosartan free base (HPLC Purity: 99.85%).

Provenance & Evidence