5-Fluorouracil → HCID 68585259, compound

HRID 1808721Notes

Reaction equation

HRID 1808721 reaction equation
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[Si:10](Cl)([CH3:13])([CH3:12])[CH3:11]>ClCCl>[Si:10]([C:7]1[NH:6][C:5](=[O:8])[N:4]([Si:10]([CH3:13])([CH3:12])[CH3:11])[C:3](=[O:9])[C:2]=1[F:1])([CH3:13])([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 33855-FluorouracilHCID 6397Chlorotrimethylsilane

Product 1

HCID 68585259HCID 68585259, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of 5-fluorouracil (130 mg, 1.0 mmol) in dichloromethane (5 mL), N,O-Bis-TMS-Acetamide (0.86 mL, 3.5 mmol) and TMS-Cl (0.1 mL) were added. After 2 h stirring at room temperature (clear solution) the reaction mixture was concentrated under reduced pressure to afford bis-TMS-5-fluorouracil.

Workup

  1. additionwere added
  2. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-520cc94bd67240f0a0fb7f01de11dd2f
Source dataset
uspto-grants-2013_01
Patent number
US08361988B2

Reaction notes

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