Hydrochloric Acid → HCID 67773346, compound

HRID 1808825Notes

Reaction equation

HRID 1808825 reaction equation
Cl.[Cl:2][C:3]1[CH:22]=[CH:21][C:6]([C:7]([N:9]([C@@H:11]([CH2:18][CH2:19][CH3:20])[CH2:12][N:13]2[CH2:16][CH:15]([OH:17])[CH2:14]2)[CH3:10])=[O:8])=[CH:5][CH:4]=1>CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]([C@@H:11]([CH2:18][CH2:19][CH3:20])[CH2:12][N:13]2[CH2:16][CH:15]([OH:17])[CH2:14]2)[CH3:10])=[O:8])=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57345459HCID 57345459, compound

Product 1

HCID 67773346HCID 67773346, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of hydrochloric acid in MeOH (0.1 M, 0.48 ml) was added (S)-4-Chloro-N-(1-(3-hydroxyazetidin-1-yl)pentan-2-yl)-N-methylbenzamide (Example 8.2A) (15 mg, 48 μmol) and allowed to evaporate. The product was dissolved in EtOAc (1 mL) and allowed to evaporate until dry.

Workup

  1. customto evaporate
  2. dissolutionThe product was dissolved in EtOAc (1 mL)
  3. customto evaporate
  4. customuntil dry

Sources & evidence

ORD record
ord-dbf877cf185740bc97626a5db9bbfc47
Source dataset
uspto-grants-2013_01
Patent number
US08361998B2

Reaction notes

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