Trifluoroacetic acid methylene chloride → HCID 66691915, compound

HRID 1808879Notes

Reaction equation

HRID 1808879 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[C:5]([Cl:21])=[CH:4][C:3]=1[Cl:22].C(O)(C(F)(F)F)=O.C(Cl)Cl>>[Cl:22][C:3]1[C:2]([NH2:1])=[N:7][C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[C:5]([Cl:21])[CH:4]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 66692180HCID 66692180, compound

Product 1

HCID 66691915HCID 66691915, compoundYield 100%

Procedure

tert-butyl 4-(6-amino-3,5-dichloropyridin-2-yl)piperazine-1-carboxylate (110 mg, 0.305 mmol,) was treated with 50% TFA/DCM for 1 h, then drained and dried in vacuum to give 3,5-dichloro-6-(piperazin-1-yl)pyridin-2-amine (110 mg, 0.305 mmol). 1H-NMR (CD3OD-d4, 500 MHz): δ7.51 (1H, s), 3.51 (4H, m), 3.31 (4H, m).

Workup

  1. customdried in vacuum

Sources & evidence

ORD record
ord-678b6d26629b4f2f9233fd12b0197121
Source dataset
uspto-grants-2013_01
Patent number
US08362004B2

Reaction notes

Loading…