4-(5-Nitro-2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester → 4-(5-Amino-2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

HRID 1808903ノート

反応式

HRID 1808903 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([N+:21]([O-])=O)[CH:18]=[CH:17][C:16]=2[O:24][CH3:25])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([NH2:21])[CH:18]=[CH:17][C:16]=2[O:24][CH3:25])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 668200114-(5-Nitro-2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

生成物 1

HCID 668198284-(5-Amino-2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester収率 94.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

4.5 g of 4-(5-nitro-2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (12.8 mmol) was dissolved in 40 mL of methanol, 1.36 g of 10% Pd/C was added and the mixture was hydrogenated under hydrogen gas for 4 h at 40° C. The reaction mixture was filtered over Celite and the filtrate evaporated to dryness in vacuo to yield 3.9 g of the title compound which was used in the next step without further purification.

後処理

  1. filtrationThe reaction mixture was filtered over Celite
  2. customthe filtrate evaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-3b86386d91e340b8bbd7201367e2a09a
出典データセット
uspto-grants-2013_01
特許番号
US08362010B2

反応ノート

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