Hydrochloric Acid → N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride

HRID 1808905Notes

Reaction equation

HRID 1808905 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[C:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH:32]([F:34])[F:33])[CH:26]=3)(=[O:24])=[O:23])[CH:18]=[CH:17][C:16]=2[O:35][CH3:36])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:37]>ClCCl.C(OCC)C>[ClH:37].[N:11]1([C:15]2[CH:20]=[C:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH:32]([F:34])[F:33])[CH:26]=3)(=[O:24])=[O:23])[CH:18]=[CH:17][C:16]=2[O:35][CH3:36])[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 668200074-[5-(3-Difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Product 1

HCID 46937291N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

0.64 g of 4-[5-(3-difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester (1.213 mmol) were dissolved in 20 mL of dichloromethane and 1.82 mL of a 2N solution of hydrochloric acid in diethyl ether was added. After stirring at room temperature for 16 h, the solvents were evaporated, the residue redissolved in water, the aqueous phase washed with dichloromethane and then lyophilized to yield the title compound.

Workup

  1. customthe solvents were evaporated
  2. dissolutionthe residue redissolved in water
  3. washthe aqueous phase washed with dichloromethane

Sources & evidence

ORD record
ord-827c3813bbcf40bd8e84e843c37974f0
Source dataset
uspto-grants-2013_01
Patent number
US08362010B2

Reaction notes

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