Formaldehyde → 3-Difluoromethoxy-n-[4-methoxy-3-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-benzenesulfonamide hydrochloride

HRID 1808906Notes

Reaction equation

HRID 1808906 reaction equation
[ClH:1].[N:2]1([C:9]2[CH:10]=[C:11]([NH:17][S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH:28]([F:30])[F:29])[CH:22]=3)(=[O:20])=[O:19])[CH:12]=[CH:13][C:14]=2[O:15][CH3:16])[CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:31]=O>[BH4-].[Na+].C(#N)C>[ClH:1].[F:29][CH:28]([F:30])[O:27][C:23]1[CH:22]=[C:21]([S:18]([NH:17][C:11]2[CH:12]=[CH:13][C:14]([O:15][CH3:16])=[C:9]([N:2]3[CH2:8][CH2:7][CH2:6][N:5]([CH3:31])[CH2:4][CH2:3]3)[CH:10]=2)(=[O:20])=[O:19])[CH:26]=[CH:25][CH:24]=1

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 46937291N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride

Product 1

HCID 497854253-Difluoromethoxy-n-[4-methoxy-3-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-benzenesulfonamide hydrochloride

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 4311764Sodium borohydrideSolvent

Procedure

The title compound was prepared from the title compound of Example 1 under reductive amination conditions employing an aqueous solution of formaldehyde and sodium borohydride in acetonitrile as solvent.

Sources & evidence

ORD record
ord-3ffd815b84f94d3592f179c2d3fab795
Source dataset
uspto-grants-2013_01
Patent number
US08362010B2

Reaction notes

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