HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-Difluoromethoxy-n-[4-methoxy-3-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-benzenesulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | N-(3-[1,4]Diazepan-1-yl-4-methoxy-phenyl)-3-difluoromethoxy-benzenesulfonamide hydrochloride | HCID 46937291 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Sodium borohydride | HCID 4311764 | — |
| Product | 3-Difluoromethoxy-n-[4-methoxy-3-(4-methyl-[1,4]diazepan-1-yl)-phenyl]-benzenesulfonamide hydrochloride | HCID 49785425 | — |
Reaction Steps
The title compound was prepared from the title compound of Example 1 under reductive amination conditions employing an aqueous solution of formaldehyde and sodium borohydride in acetonitrile as solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362010B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-3ffd815b84f94d3592f179c2d3fab795 |
| Source note | uspto-grants-2013_01 |