HCID 59587968, compound → HCID 44595150, compound

HRID 1808912Notes

Reaction equation

HRID 1808912 reaction equation
[N:1]([C@@H:4]1[C@@H:8]([O:9][CH2:10][C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[CH2:7][N:6]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:5]1)=[N+:2]=[N-:3]>C1(C)C=CC=CC=1>[F:19][C:15]1[CH:14]=[C:13]([C:12]2[N:3]=[N:2][N:1]3[C:11]=2[CH2:10][O:9][C@H:8]2[CH2:7][N:6]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:5][C@H:4]32)[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 1

HCID 59587968HCID 59587968, compound

Product 1

HCID 44595150HCID 44595150, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Example 56 can be prepared in the same manner as example 53 from (3S,4S)-tert-butyl 3-azido-4-(3-(3-fluorophenyl)prop-2-ynyloxy)pyrrolidine-1-carboxylate (143 mg, 0.39 mmol) and toluene (12 ml), afforded the titled compound (124 mg, 86%) as white solid. M.p. 249-250° C.

Sources & evidence

ORD record
ord-505716592ddd4df89eae5181fc7c358c
Source dataset
uspto-grants-2013_01
Patent number
US08362011B2

Reaction notes

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