HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(5,6-Dimethyl-1,4-diazepan-1-yl)-6-fluoroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(6-fluoroquinazolin-2-yl)-6,7-dimethyl-1,4-diazepane-1-carboxylate | HCID 59527664 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(5,6-Dimethyl-1,4-diazepan-1-yl)-6-fluoroquinazoline | HCID 59527668 | — |
Reaction Steps
Hydrogen chloride gas was bubbled through a 0° C. solution of compound 1-10 (338 mg, 0.9 mmol) in ethyl acetate (5 mL) for 1 minute. The reaction was sealed and stirred for 40 minutes. Concentration in vacuo gave the titled compound as a white solid. Data for 1-11: LC/MS: m/z (M+CH3CN)=315.2 found; 315.3 calculated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362009B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-90025d558e41422a9c773ad9a2f4c69c |
| Source note | uspto-grants-2013_01 |