Hydrochloric Acid → 2-(5,6-Dimethyl-1,4-diazepan-1-yl)-6-fluoroquinazoline

HRID 1808918Notes

Reaction equation

HRID 1808918 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([N:13]1[CH2:19][CH:18]([CH3:20])[CH:17]([CH3:21])[N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)[N:7]=[CH:6]2>C(OCC)(=O)C>[CH3:21][CH:17]1[CH:18]([CH3:20])[CH2:19][N:13]([C:8]2[N:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([F:2])[CH:4]=3)[N:9]=2)[CH2:14][CH2:15][NH:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59527664Tert-butyl 4-(6-fluoroquinazolin-2-yl)-6,7-dimethyl-1,4-diazepane-1-carboxylate

Product 1

HCID 595276682-(5,6-Dimethyl-1,4-diazepan-1-yl)-6-fluoroquinazoline

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride gas was bubbled through a 0° C. solution of compound 1-10 (338 mg, 0.9 mmol) in ethyl acetate (5 mL) for 1 minute. The reaction was sealed and stirred for 40 minutes. Concentration in vacuo gave the titled compound as a white solid. Data for 1-11: LC/MS: m/z (M+CH3CN)=315.2 found; 315.3 calculated.

Workup

  1. customThe reaction was sealed
  2. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-90025d558e41422a9c773ad9a2f4c69c
Source dataset
uspto-grants-2013_01
Patent number
US08362009B2

Reaction notes

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