反应详情

Potassium hydroxide (0.56 g, 10 mmol) in water (2 mL) was added to 5-(tetrahydro-pyran-4-yl)-thiophene-3-carboxylic acid ethyl ester (3.36 mmol) in IMS (6 mL). The reaction mixture was stirred for 1 hour then water was added and the mixture acidified to pH 7 with 1 N hydrochloric acid and then extracted with diethyl ether. The organic solution was dried over magnesium sulphate, filtered and the solvent evaporated to give the title compound (613 mg). LCMS m/z 211 [M−H]− RT=2.53 min (Analytical Method 4).

1. extractionextracted with diethyl ether
2. dry with materialThe organic solution was dried over magnesium sulphate
3. filtrationfiltered
4. customthe solvent evaporated