反应详情

To a solution of cis-(octahydro-quinolin-1-yl)-(5-piperidin-4-yl-thiophen-3-yl)-methanone (CC-033) (0.061 g, 0.18 mmol) in acetonitrile (1 mL) was added triethylamine (0.55 mmol), HATU (0.21 mmol) and 1-piperidinepropionic (0.21 mmol). The reaction mixture was stirred for 4 hours, and then water (1 mL) was added and the resulting solution was purified by HPLC, eluting with 10%-98% acetonitrile in water (containing 20 mM triethylamine). The fractions containing the desired product were concentrated under vacuum to give the title compound as a colourless oil (0.013 g). LCMS m/z 472.00 [M+H]+ RT=7.07 min (Analytical Method 2).

1. customthe resulting solution was purified by HPLC
2. washeluting with 10%-98% acetonitrile in water (containing 20 mM triethylamine)
3. additionThe fractions containing the desired product
4. concentrationwere concentrated under vacuum