Hydrochloric Acid → HCID 59542561, compound

HRID 1809085Notes

Reaction equation

HRID 1809085 reaction equation
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][CH:7]=1)=[O:5])C.[ClH:13]>[OH-].[Na+].C(O)C>[Cl:13][C:7]1[S:8][C:9]([CH2:11][CH3:12])=[CH:10][C:6]=1[C:4]([OH:3])=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 12588559Ethyl 5-ethylthiophene-3-carboxylate

Product 1

HCID 59542561HCID 59542561, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
140 °C

Procedure

5-Ethyl-thiophene-3-carboxylic acid ethyl ester (0.83 g, 3.8 mmol) was dissolved in a solution of aqueous sodium hydroxide (1 M, 6 mL) and ethanol (4 mL). The mixture was then heated to 140° C. for 10 minutes using microwave irradiation. The reaction mixture was acidified with 1 N hydrochloric acid and the resulting precipitate was isolated by filtration, washed with water and then dried under vacuum to give the title compound (0.53 g). 1H NMR (400 MHz, DMSO-d6): δ 7.05 (s, 1H), 2.75 (q, 2H), 1.4 (t, 3H), 1.2 (t, 3H).

Workup

  1. custommicrowave irradiation
  2. customthe resulting precipitate was isolated by filtration
  3. washwashed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-eb0f1c4f528a4689a4cbc1885d7ca301
Source dataset
uspto-grants-2013_01
Patent number
US08362008B2

Reaction notes

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