反应详情

4-[4-(Azepane-1-carbonyl)-thiophen-2-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.094 g) was dissolved in TFA (1 mL) and DCM (1 mL). The mixture was stirred for 1 hour and then the solvent evaporated. The residue was purified using a SCX-2 column. After washing with methanol and acetonitrile, the desired compound was washed from the column with ammonia (2 M in MeOH). Evaporation gave the title compound as a clear colourless oil (0.068 g). LCMS m/z 291.07 [M+H]+ RT=5.14 min (Analytical Method 2).

1. customthe solvent evaporated
2. customThe residue was purified
3. washAfter washing with methanol and acetonitrile
4. washthe desired compound was washed from the column with ammonia (2 M in MeOH)
5. customEvaporation