Aniline → HCID 86652457, compound

HRID 1809124Notes

Reaction equation

HRID 1809124 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9]([C:11]3[C:16]4[O:17][CH2:18][CH2:19][NH:20][C:15]=4[CH:14]=[CH:13][CH:12]=3)[NH:8][C:7]=2[CH:21]=1.Cl[C:25]1[C:30]([C:31]([F:34])([F:33])[F:32])=[CH:29][CH:28]=[CH:27][N:26]=1.C1(N)C=CC=CC=1.ClC1C(Cl)=CC=CN=1>>[F:23][C:2]([F:22])([F:1])[C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9]([C:11]3[C:16]4[O:17][CH2:18][CH2:19][N:20]([C:25]5[C:30]([C:31]([F:34])([F:33])[F:32])=[CH:29][CH:28]=[CH:27][N:26]=5)[C:15]=4[CH:14]=[CH:13][CH:12]=3)[NH:8][C:7]=2[CH:21]=1

Participants

5

Reactant 4

HCID 6115AnilineHCID 169882,3-DichloropyridineHCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 67094559HCID 67094559, compound

Product 1

HCID 86652457HCID 86652457, compoundYield 91%

Procedure

The procedure of Example 6 was repeated except for using 8-(6-(trifloromethyl)-1H-benzo[d]imidazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine and 2-chloro-3-trifluoromethylpyridine instead of 445-tert-butyl-1H-benzo[d]imidazol-2-yl)benzenamine and 2,3-dichloropyridine in Example 6 respectively to obtain the title compound (4.2 g, yield: 91%).

Sources & evidence

ORD record
ord-b949c420eed446c6b7794103814ff1a3
Source dataset
uspto-grants-2013_01
Patent number
US08362012B2

Reaction notes

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