Methyl 3-cyano-4-(cyclopropylmethoxy)benzoate → 3-Cyano-4-(cyclopropylmethoxy)benzoic acid

HRID 1809522Notes

Reaction equation

HRID 1809522 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH:15]1[CH2:17][CH2:16]1)[C:6]([O:8]C)=[O:7])#[N:2].C(C1C=C(C=C(OC(C)C)C=1)C(O)=O)#N>>[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH:15]1[CH2:16][CH2:17]1)[C:6]([OH:8])=[O:7])#[N:2]

Participants

3

Reactant 2

HCID 66877477Methyl 3-cyano-4-(cyclopropylmethoxy)benzoateHCID 671962143-Cyano-5-isopropoxybenzoic acid

Product 1

HCID 668780013-Cyano-4-(cyclopropylmethoxy)benzoic acid

Procedure

Prepared from methyl 3-cyano-4-(cyclopropylmethoxy)benzoate according to the procedure for 3-cyano-5-isopropoxybenzoic acid. LCMS-ESI (m/z) calculated for C12H11NO3; 217.2; no ink observed, tR=2.92 min. 1H NMR (400 MHz, CDCl3) δ 8.24-8.08 (m, 2H), 7.32 (d, J=8.9 Hz, 1H), 4.09 (d, J=7.1 Hz, 2H), 1.28 (s, 1H), 0.71-0.52 (m, 2H), 0.49-0.31 (m, 2H).

Sources & evidence

ORD record
ord-28480cd2677046dda98965e0328858b7
Source dataset
uspto-grants-2013_01
Patent number
US08362048B2

Reaction notes

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