Sodium Hydroxide → HCID 86641098, compound

HRID 1809600Notes

Reaction equation

HRID 1809600 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[C:18]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:17][C:16]([C:26]([F:29])([F:28])[F:27])=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>CO>[O:19]([C:18]1[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=[C:16]([C:26]([F:29])([F:27])[F:28])[CH:17]=1)[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86641097HCID 86641097, compound

Product 1

HCID 86641098HCID 86641098, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

1-Benzoyl-3-(3-phenoxy-5-(trifluoromethyl)pyridin-2-yl)thiourea (0.230 g, 0.551 mmol) was dissolved in methanol (7 mL) and a 1M solution of sodium hydroxide (3.00 mL, 3.00 mmol) was added. The resulting mixture was heated to 50° C. and agitated for one hour. Methanol was then evaporated and the resulting slurry was filtered and solids were washed with water and dried to give 1-(3-phenoxy-5-(trifluoromethyl)pyridin-2-yl)thiourea (0.147 g, 85.2% yield) as white solid.

Workup

  1. customMethanol was then evaporated
  2. filtrationthe resulting slurry was filtered
  3. washsolids were washed with water
  4. customdried

Sources & evidence

ORD record
ord-d0e2e905e3fa498d9fa52947f0386837
Source dataset
uspto-grants-2013_01
Patent number
US08362037B2

Reaction notes

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