反应详情

温度

65 °C

3-(6-Chloro-3-methylpyridazin-4-yloxy)pyridin-2-amine (3.0 g, 12.7 mmol) was charged with MeOH (150 mL). Pd/C (0.67 g, 0.63 mmol) was added followed by ammonium formate (2.23 g, 35.5 mmol). The mixture was heated at 65° C. overnight. The solution was cooled and filtered through GF/F paper. The filtrate was concentrated and the residue was dissolved in dichloromethane and saturated NaHCO3. The organic layer was separated and the aqueous layer was extracted twice with dichloromethane. The combined organics were dried and concentrated to give 3-(3-methylpyridazin-4-yloxy)pyridin-2-amine (1.85 g, 72%) as a solid.

1. temperatureThe solution was cooled
2. filtrationfiltered through GF/F paper
3. concentrationThe filtrate was concentrated
4. dissolutionthe residue was dissolved in dichloromethane
5. customThe organic layer was separated
6. extractionthe aqueous layer was extracted twice with dichloromethane
7. customThe combined organics were dried
8. concentrationconcentrated