Sodium Hydroxide → 3-Amino-1-phenylpropan-1-ol

Temperature

25 °C

3-oxo-3-phenylpropanenitrile (30 g, 207 mmol) in dry THF (300 mL) drop-wise at 0° C. under nitrogen atmosphere. The mixture was warmed to 25° C. and then heated at 70° C. for 2 hours. After cooling to 0° C., a saturated solution of sodium hydroxide was added drop-wise and extracted with dichloromethane (200 mL). The organic solution was dried over anhydrous sodium sulfate and concentrated to dryness. The residue was purified by column chromatography (methanol:dichloromethane, 1:10) to afford 3-amino-1-phenyl-propan-1-ol. (Yield 30 g, crude).

1. customat 0° C.
2. temperatureheated at 70° C. for 2 hours
3. temperatureAfter cooling to 0° C.
4. extractionextracted with dichloromethane (200 mL)
5. dry with materialThe organic solution was dried over anhydrous sodium sulfate
6. concentrationconcentrated to dryness
7. customThe residue was purified by column chromatography (methanol:dichloromethane, 1:10)

ORD record

ord-26cf154121b9405b9f15a8e0be77b9da

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08362023B2