Hydrazine → HCID 178478327, compound

HRID 1809698Notes

Reaction equation

HRID 1809698 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([C:8]([C:10]2[C:11](Cl)=[N:12][C:13]([Cl:16])=[N:14][CH:15]=2)=O)[CH:5]=[CH:4][CH:3]=1.[NH2:18][NH2:19]>C1COCC1>[Br:1][C:2]1[N:7]=[C:6]([C:8]2[C:10]3[C:11](=[N:12][C:13]([Cl:16])=[N:14][CH:15]=3)[NH:19][N:18]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86667958(6-Bromo-pyridin-2-yl)-(2,4-dichloro-pyrimidin-5-yl)-methanone

Product 1

HCID 178478327HCID 178478327, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of (6-bromo-pyridin-2-yl)-(2,4-dichloro-pyrimidin-5-yl)-methanone (from Example 29 supra) (2.42 g, 7.54 mmol) in THF (30 mL) was added hydrazine (454 mg, 9.08 mmol) and the mixture was stirred for 30 minutes at room temperature and then at 50° C. for 1 hour. The solvent was then removed and the solid was washed with water and dried to give crude 3-(6-bromo-pyridin-2-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine as a yellow solid. (Yield 1.7 g, crude).

Workup

  1. waitat 50° C. for 1 hour
  2. customThe solvent was then removed
  3. washthe solid was washed with water
  4. customdried

Sources & evidence

ORD record
ord-1e3d297cf3f3499da7665a2bdce51aec
Source dataset
uspto-grants-2013_01
Patent number
US08362023B2

Reaction notes

Loading…