反应详情

To a stirred solution of (6-bromo-pyridin-2-yl)-(2,4-dichloro-pyrimidin-5-yl)-methanone (from Example 29 supra) (2.42 g, 7.54 mmol) in THF (30 mL) was added hydrazine (454 mg, 9.08 mmol) and the mixture was stirred for 30 minutes at room temperature and then at 50° C. for 1 hour. The solvent was then removed and the solid was washed with water and dried to give crude 3-(6-bromo-pyridin-2-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine as a yellow solid. (Yield 1.7 g, crude).

1. waitat 50° C. for 1 hour
2. customThe solvent was then removed
3. washthe solid was washed with water
4. customdried