反应详情

To a solution of crude [4-(3-{2-[2-tert-butoxycarbonylamino-1-(3-chloro-phenyl)-ethylamino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester (30 mg, 0.044 mmol) in methanol (40 mL) was bubbled in HCl (gas) for 3 hours at room temperature. Then the mixture was concentrated by evaporation to afford N-(3-{2-[2-amino-1-(3-chloro-phenyl)-ethylamino]-pyrimidin-4-yl}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-cyclohexane-1,4-diamine; hydrochloride. (Yield 24 mg, 93.3%).

1. concentrationThen the mixture was concentrated by evaporation