Hydrochloric Acid → HCID 178478113, compound

HRID 1809782Notes

Reaction equation

HRID 1809782 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[N:21]=[C:20]3[NH:22][N:23]=[C:24]([C:25]4[CH:30]=[CH:29][N:28]=[C:27]([NH:31][CH2:32][C:33]5[CH:38]=[CH:37][CH:36]=[C:35]([Cl:39])[CH:34]=5)[N:26]=4)[C:19]3=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCO>[Cl:39][C:35]1[CH:34]=[C:33]([CH:38]=[CH:37][CH:36]=1)[CH2:32][NH:31][C:27]1[N:26]=[C:25]([C:24]2[C:19]3[C:20](=[N:21][C:16]([NH:15][CH2:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[N:17][CH:18]=3)[NH:22][N:23]=2)[CH:30]=[CH:29][N:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451972HCID 178451972, compound

Product 1

HCID 178478113HCID 178478113, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-({3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester (200 mg, 0.36 mmol) in EtOH (4 mL) was added conc. HCl (4 mL). The reaction mixture was stirred at room temperature for 15 hours. The solvent was then removed and the residue was purified by prep-HPLC to afford {3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-ylmethyl-amine; hydrochloride. (Yield 60 mg, 30.0%).

Workup

  1. customThe solvent was then removed
  2. customthe residue was purified by prep-HPLC

Sources & evidence

ORD record
ord-214a706a0b044e008b9f9ab7ddba5f01
Source dataset
uspto-grants-2013_01
Patent number
US08362023B2

Reaction notes

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