反应详情

To a solution of 4-(2-{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (90 mg, 0.16 mmol) in EtOH (10 mL) was added conc. HCl (5 mL). The reaction mixture was stirred at room temperature for 15 hours. The solvent was removed to afford {3-[2-(3-Chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-piperazin-1-yl-ethyl)-amine; hydrochloride. (Yield 46 mg).

1. customThe solvent was removed