Hydrochloric Acid → HCID 178478114, compound

HRID 1809787Notes

Reaction equation

HRID 1809787 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16][C:17]2[N:22]=[C:21]3[NH:23][N:24]=[C:25]([C:26]4[CH:31]=[CH:30][N:29]=[C:28]([NH:32][CH2:33][C:34]5[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[CH:35]=5)[N:27]=4)[C:20]3=[CH:19][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCO>[Cl:40][C:36]1[CH:35]=[C:34]([CH:39]=[CH:38][CH:37]=1)[CH2:33][NH:32][C:28]1[N:27]=[C:26]([C:25]2[C:20]3[C:21](=[N:22][C:17]([NH:16][CH2:15][CH2:14][N:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)=[N:18][CH:19]=3)[NH:23][N:24]=2)[CH:31]=[CH:30][N:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452331HCID 178452331, compound

Product 1

HCID 178478114HCID 178478114, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-(2-{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (90 mg, 0.16 mmol) in EtOH (10 mL) was added conc. HCl (5 mL). The reaction mixture was stirred at room temperature for 15 hours. The solvent was removed to afford {3-[2-(3-Chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-(2-piperazin-1-yl-ethyl)-amine; hydrochloride. (Yield 46 mg).

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-5daef8359fb5444eb43abfc974f833a7
Source dataset
uspto-grants-2013_01
Patent number
US08362023B2

Reaction notes

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