Hydrochloric Acid → HCID 59556102, compound

HRID 1809945Notes

Reaction equation

HRID 1809945 reaction equation
[CH3:1][C@H:2]1[CH2:6][C@@H:5]([NH:7][C:8](=[O:23])[CH2:9][NH:10][C:11](=[O:22])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH2:4][N:3]1C(OC(C)(C)C)=O.Cl>CO.O1CCOCC1>[CH3:1][C@@H:2]1[NH:3][CH2:4][C@H:5]([NH:7][C:8](=[O:23])[CH2:9][NH:10][C:11](=[O:22])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:19])[F:20])[CH:13]=2)[CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59556127HCID 59556127, compound

Product 1

HCID 59556102HCID 59556102, compoundYield 121.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

The intermediate of step F (0.6 g, 1.4 mmol) was dissolved in MeOH (3 mL) and a solution of 4 N HCl in dioxane (3 mL). After being stirred at room temperature for 4 hours, the solution was concentrated to give 0.56 g of the title compound. MS calculated (M+H)+330. Found 330.2.

Workup

  1. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-97a9fe9c24c54aac8f924afe76d35252
Source dataset
uspto-grants-2013_01
Patent number
US08362003B2

Reaction notes

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