3-Butyn-1-OL → HCID 178449564, compound

HRID 1810060Notes

Reaction equation

HRID 1810060 reaction equation
C[C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:27]2[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]2)[CH2:17][CH2:18][CH2:19][CH2:20]C2C=CC=CC=2)=[O:15])=[N:10][CH:9]=1)(C)[C:3]([OH:5])=[O:4].C(O)CC#C.C(OC(=O)C(SC1SC(N)=NC=1)C)C>>[CH2:17]([N:16]([C@H:27]1[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]1)[C:14](=[O:15])[NH:13][C:11]1[S:12][C:8]([S:7][CH2:2][C:3]([OH:5])=[O:4])=[CH:9][N:10]=1)[CH2:18][C:19]#[CH:20]

Participants

4

Reactant 3

HCID 135663-Butyn-1-OLHCID 86610213(2-Aminothiazole-5-ylsulfanyl)-propionic acid ethyl esterHCID 178460760HCID 178460760, compound

Product 1

HCID 178449564HCID 178449564, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-(4-phenyl-butyl)-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 3-butyn-1-ol and (2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-39c6d175a42f40bc98d9aeea8d598b4a
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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