Phenethyl bromide → HCID 178496612, compound

HRID 1810061Notes

Reaction equation

HRID 1810061 reaction equation
C[C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28](C)[CH2:27][CH2:26]2)[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:15])=[N:10][CH:9]=1)(C)[C:3]([OH:5])=[O:4].[CH3:32][O:33][C@H]1CC[C@H](N)CC1.C1(CCBr)C=CC=CC=1>C(OC(=O)C)C>[CH3:32][O:33][C@H:28]1[CH2:29][CH2:30][C@H:25]([N:16]([CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:2][C:3]([OH:5])=[O:4])=[CH:9][N:10]=2)[CH2:26][CH2:27]1

Participants

5

Reactant 3

HCID 7666Phenethyl bromideHCID 178460750HCID 178460750, compoundHCID 178496609HCID 178496609, compound

Product 1

HCID 178496612HCID 178496612, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-phenethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid using trans-4-methoxy-cyclohexylamine (prepared as described in J. Med. Chem. 1977, 20, 279-290), 2-phenylethylbromide and 2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-40fa0ec531ca47b09744871652b7c100
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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