3-Bromopropionitrile → HCID 178461330, compound

HRID 1810066Notes

Reaction equation

HRID 1810066 reaction equation
C[C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[CH2:17][CH2:18][C:19]2C=CC=CC=2)=[O:15])=[N:10][CH:9]=1)(C)[C:3]([OH:5])=[O:4].BrCCC#[N:36]>C(OC(=O)C)C>[C:19]([CH2:18][CH2:17][N:16]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:14](=[O:15])[NH:13][C:11]1[S:12][C:8]([S:7][CH2:2][C:3]([OH:5])=[O:4])=[CH:9][N:10]=1)#[N:36]

Participants

4

Reactant 2

HCID 170203-BromopropionitrileHCID 178460750HCID 178460750, compound

Product 1

HCID 178461330HCID 178461330, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-phenethyl-ureido]-thiazol-5-ylsulfanyl}-propionic acid using 3-bromopropionitrile and 2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-2e2e40de0a3942a0b7099304501a7ca4
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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