2-Pyridinecarboxaldehyde → HCID 178461309, compound

HRID 1810068Notes

Reaction equation

[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]([CH2:22]C2C=CN=CC=2)[C:9](=[O:21])[NH:10][C:11]2[S:12][C:13]([S:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:14][N:15]=2)[CH2:4][CH2:3]1.C([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1)=O>>[CH3:1][C@H:2]1[CH2:3][CH2:4][C@H:5]([N:8]([CH2:22][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=2)[C:9](=[O:21])[NH:10][C:11]2[S:12][C:13]([S:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:14][N:15]=2)[CH2:6][CH2:7]1

Participants

Reactant 2

HCID 142732-Pyridinecarboxaldehyde

HCID 178461311HCID 178461311, compound

Product 1

HCID 178461309HCID 178461309, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[3-(trans-4-methyl-cyclohexyl)-3-pyridin-4-ylmethyl-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 2-formyl-pyridine.

Workup

customThe compound was prepared

Sources & evidence

ORD record: ord-d0d12d30c4ef4f9e8c88f61d642c06e6
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08362049B2

Reaction notes

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