Bromobenzene → HCID 178461323, compound

HRID 1810071Notes

Reaction equation

HRID 1810071 reaction equation
CS([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][CH2:13][CH2:14][N:15]([C@H:29]2[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]2)[C:16](=[O:28])[NH:17][C:18]2[S:19][C:20]([S:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:21][N:22]=2)=[CH:7][CH:6]=1)(=O)=O.BrC1C=CC=CC=1>>[CH3:35][C@H:32]1[CH2:33][CH2:34][C@H:29]([N:15]([CH2:14][CH2:13][C:12]#[C:11][C:8]2[CH:7]=[CH:6][CH:5]=[CH:10][CH:9]=2)[C:16](=[O:28])[NH:17][C:18]2[S:19][C:20]([S:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:21][N:22]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 7961BromobenzeneHCID 178504741HCID 178504741, compound

Product 1

HCID 178461323HCID 178461323, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[3-[4-(4-Methanesulfonyl-phenyl)-but-3-ynyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using bromobenzene.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-3521a006e1be410cbb15c35117e51be2
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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