Bromomethylcyclopropane → HCID 178461336, compound

HRID 1810083Notes

Reaction equation

HRID 1810083 reaction equation
ClC1C=C[CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16][CH2:17]C(C)(C)C(O)=O)=[CH:14][N:15]=1.BrCC1CC1.C([O:43][C:44](=[O:53])CSC1SC(N)=NC=1)C>>[CH:3]1([CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:9](=[O:24])[NH:10][C:11]2[S:12][C:13]([S:16][CH2:17][C:44]([OH:53])=[O:43])=[CH:14][N:15]=2)[CH2:33][CH2:32]1

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178454946HCID 178454946, compound

Product 1

HCID 178461336HCID 178461336, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using bromomethyl-cyclopropane and (2-aminothiazol-5-ylsulfanyl)acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e8964e6b510348b9b2cc5722ee211bdd
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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