HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1810120Generated: October 27, 2026
Chloral Hydrate → N-(4-Fluoro-3-methoxyphenyl)-2-(hydroxyimino)ethanamide
https://huagongshe.com/reaction/1810120
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | 4-Fluoro-3-methoxyaniline | HCID 2774533 | — |
| Reactant | Hydroxyamine chloride | HCID 21878317 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(4-Fluoro-3-methoxyphenyl)-2-(hydroxyimino)ethanamide | HCID 86651834 | — |
Reaction Steps
118.4 g of sodium sulfate, 26.3 g of hydroxylamine chloride and 20.89 g of chloral hydrate are added, in this order, to a suspension of 14.7 g of 4-fluoro-3-methoxyaniline in 695 ml of water and 35 ml of 2N hydrochloric acid. The reaction mixture is heated at 55° C. for 6 hours. It is cooled to approximately 15° C. The expected compound is obtained and is filtered off, washed and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08362067B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-ec120bb1fec5478da64a12ee2b6452f0 |
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| Source note | uspto-grants-2013_01 |
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