Chloral Hydrate → N-(4-Fluoro-3-methoxyphenyl)-2-(hydroxyimino)ethanamide

HRID 1810120Notes

Reaction equation

S([O-])([O-])(=O)=O.[Na+].[Na+].[Cl-].[NH2:9][OH:10].Cl[C:12](Cl)(Cl)[CH:13]([OH:15])O.[F:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][C:20]=1[O:26][CH3:27]>O.Cl>[F:18][C:19]1[CH:25]=[CH:24][C:22]([NH:23][C:13](=[O:15])[CH:12]=[N:9][OH:10])=[CH:21][C:20]=1[O:26][CH3:27]

Participants

Conditions

Temperature: 55 °C

Procedure

118.4 g of sodium sulfate, 26.3 g of hydroxylamine chloride and 20.89 g of chloral hydrate are added, in this order, to a suspension of 14.7 g of 4-fluoro-3-methoxyaniline in 695 ml of water and 35 ml of 2N hydrochloric acid. The reaction mixture is heated at 55° C. for 6 hours. It is cooled to approximately 15° C. The expected compound is obtained and is filtered off, washed and dried.

Workup

temperatureIt is cooled to approximately 15° C

Sources & evidence

ORD record: ord-ec120bb1fec5478da64a12ee2b6452f0
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08362067B2

Reaction notes

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