Dichloromethane → 4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyrazol-1-yl)-piperidine-1-carboxamide

HRID 181014Notes

Reaction equation

HRID 181014 reaction equation
[CH3:32][Si:33]([CH3:34])([CH3:35])[N:36]=[C:37]=[O:38].[CH:39]([N:40]([CH2:41][CH3:42])[CH:43]([CH3:44])[CH3:45])([CH3:46])[CH3:47].[Cl:1][c:2]1[c:3]([CH:10]([CH3:11])[c:12]2[cH:13][nH:14][c:15]3[n:16][cH:17][c:18](-[c:21]4[cH:22][n:23][n:24]([CH:26]5[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]5)[cH:25]4)[cH:19][c:20]23)[c:4]([Cl:9])[cH:5][cH:6][c:7]1[F:8].[Cl:48][CH2:49][Cl:50]>>[Cl:1][c:2]1[c:3]([CH:10]([CH3:11])[c:12]2[cH:13][nH:14][c:15]3[n:16][cH:17][c:18](-[c:21]4[cH:22][n:23][n:24]([CH:26]5[CH2:27][CH2:28][N:29]([C:37]([NH2:36])=[O:38])[CH2:30][CH2:31]5)[cH:25]4)[cH:19][c:20]23)[c:4]([Cl:9])[cH:5][cH:6][c:7]1[F:8]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 70696Trimethylsilyl isocyanateHCID 81531DiisopropylethylamineHCID 461964113-[1-(2,6-Dichloro-3-fluorophenyl)ethyl]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 673629124-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyrazol-1-yl)-piperidine-1-carboxamide

Sources & evidence

ORD record
ord-dcc2bee4bc26451e9c9d2e03d028ff81
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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