Water → HCID 57458797, compound

HRID 1810311Notes

Reaction equation

HRID 1810311 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7].C(N(CC)CC)C.[CH3:23][N:24]=[C:25]=[O:26].O>C(Cl)Cl>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([C:12]([F:13])([F:14])[F:15])=[CH:8][C:3]=1[CH2:4][N:5]([CH2:6][CH3:7])[C:25]([NH:24][CH3:23])=[O:26]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 666039992-Bromo-N-ethyl-5-(trifluoromethyl)benzenemethanamine

Product 1

HCID 57458797HCID 57458797, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To (2-bromo-5-trifluoromethyl-benzyl)-ethyl-amine (0.5 g, 1.8 mmol) in CH2Cl2 (5 mL) was added triethylamine (0.5 mL, 3.5 mmol), followed by methyl isocyanate (0.121 g, 2.2 mmol), and the reaction was stirred at room temperature under N2 for 30 minutes. The mixture was worked-up with CH2Cl2 and H2O, and the residue was purified by silica gel chromatography to give the title compound.

Workup

  1. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-46d1fdb5b0a845e6be17ece5ec2e2c24
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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