HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86651110, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | HCID 86651109 | HCID 86651109 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86651110 | HCID 86651110 | — |
Reaction Steps
(R)-2-(2′-Ethylaminomethyl-5,4′-bis-trifluoromethyl-biphenyl-3-yl)-propionic acid methyl ester (0.10 mmol) in CH2Cl2 was treated with triethylamine (0.03 mL, 0.20 mmol) and benzyl isocyanate (0.02 mL, 0.20 mmol) at room temperature for 2 hours. The mixture was worked up with CH2Cl2 and H2O to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08362044B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-6b8b6fbea51a4dcf909c5826691b759f |
| Source note | uspto-grants-2013_01 |